Dr. Ruiz-Lozano's research focuses on the developmental pathways that induce the formation of the coronary vasculature.
Pilar Ruiz-Lozano earned her Ph.D. in Biochemistry and Molecular Biology from the University of Barcelona, Spain in 1992.
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Coronary development is regulated by ATP-dependent SWI/SNF chromatin remodeling component BAF180.
Huang X, Gao X, Diaz-Trelles R, Ruiz-Lozano P, Wang Z
Dev Biol. 2008 Jul 15;319(2):258-66
Stem cells as in vitro models of disease.
Ruiz-Lozano P, Rajan P
Curr Stem Cell Res Ther. 2007 Dec;2(4):280-92
Epicardium-derived progenitor cells require beta-catenin for coronary artery formation.
Zamora M, Männer J, Ruiz-Lozano P
Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18109-14
MicroRNA-133 controls cardiac hypertrophy.
Carè A, Catalucci D, Felicetti F, Bonci D, Addario A, Gallo P, Bang ML, Segnalini P, Gu Y, Dalton ND, Elia L, Latronico MV, Høydal M, Autore C, Russo MA, Dorn GW, Ellingsen O, Ruiz-Lozano P, Peterson KL, Croce CM, Peschle C, Condorelli G
Nat Med. 2007 May;13(5):613-8
Distinct roles of HF-1b/Sp4 in ventricular and neural crest cells lineages affect cardiac conduction system development.
St Amand TR, Lu JT, Zamora M, Gu Y, Stricker J, Hoshijima M, Epstein JA, Ross JJ, Ruiz-Lozano P, Chien KR
Dev Biol. 2006 Mar 15;291(2):208-17
Epicardial retinoid X receptor alpha is required for myocardial growth and coronary artery formation.
Merki E, Zamora M, Raya A, Kawakami Y, Wang J, Zhang X, Burch J, Kubalak SW, Kaliman P, Izpisua Belmonte JC, Chien KR, Ruiz-Lozano P
Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18455-60
Predominant fusion of bone marrow-derived cardiomyocytes.
Andrade J, Lam JT, Zamora M, Huang C, Franco D, Sevilla N, Gruber PJ, Lu JT, Ruiz-Lozano P
Cardiovasc Res. 2005 Dec 1;68(3):387-93
Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum.
Kaliman P, Catalucci D, Lam JT, Kondo R, Gutiérrez JC, Reddy S, Palacín M, Zorzano A, Chien KR, Ruiz-Lozano P
J Biol Chem. 2005 Mar 4;280(9):8016-21
Pilar Ruiz-Lozano's Research Focus
Coronary artery disease is a leading clinical problem in the western countries and it can not be cured (www.americanheart.org
). The coronary arteries have a distinct embryological origin that may explain their differences in responding to environmental stimuli. Research in the Ruiz-Lozano laboratory focuses in the developmental pathways that induce the formation of the coronary vasculature and how coronary precursors influence cardiac morphogenesis and function.
Current projects in the laboratory include: 1. The determination of the fate of coronary progenitor cells from the epicardium and their response to growth signals. 2. The potential of epicardial cells to modulate cardiac morphogenesis. 3. Adaptation mechanisms of the heart to stress and aging.
Among the achievements of the laboratory is the generation of the first animal model targeting specific mutations to coronary progenitor cells and the identification of genetic pathways that regulate cardiac growth and coronary formation. A major effort is committed to the isolation of progenitor cells and tissue repair.
About Pilar Ruiz-Lozano
Pilar Ruiz-Lozano earned her Ph.D. in Biochemistry and Molecular Biology from the University of Barcelona, Spain in 1992. Dr. Ruiz-Lozano trained in Case Western Reserve, Paris XII and the University of California, San Diego. She initiated her independent work at the Institute of Molecular Medicine UCSD and was recruited to Sanford-Burnham Medical Research Institute in 2005.