Current Postdoctoral Training Opportunities

Current Postdoctoral Training Opportunities

Tumor Initiation and Maintenance

La Jolla, CA
Postdoctoral Training Opportunity
Organic Chemist
Principal Investigator
Marcia Dawson, Ph.D.
Research Description
A Postdoctoral position is available in Synthetic Organic Chemistry.
Requirements
Candidates must have a Ph.D. and be experienced in multi-step natural product synthesis and characterization. Must be self-motivated and able to communicate effectively both orally and written. Interested applicants should submit a copy of their CV to: Dr. Marcia Dawson at mdawson@sanfordburnham.org.
La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Position
Principal Investigator
Charles Spruck, Ph.D.
Research Description
A Postdoctoral position is available to work on various projects that will explore the molecular regulations of cell division control and define how alterations of these processes contribute to cancer development and progression. An emphasis of these projects will be the ubiquitin proteasome system (UPS) and the role of protein destruction in cancer.
Requirements
Candidates must have a Ph.D. and have a strong background in molecular biology techniques. Experience in the fields of DNA damage response and ubiquitin-dependent proteolysis are preferred, but not required. Interested applicants should submit a copy of their CV and a list of at least three professional references to: Dr. Charles Spruck at cspruck@sanfordburnham.org.
La Jolla, CA
Postdoctoral Training Opportunity
Principal Investigator
Matthew Petroski, Ph.D.
Research Description
A postdoctoral position is available in the laboratory of Matthew Petroski, Ph.D. within the Tumor Initiation and Maintenance Program of the NCI-designated Cancer Center at Sanford-Burnham Medical Research Institute in La Jolla, California. Our research focuses on understanding the functions and regulation of ubiquitin and ubiquitin-like proteins. A major emphasis is on identifying and characterizing targets of ubiquitin and ubiquitin-like protein post-translational modification systems for developing therapeutics for diseases such as cancer.
Requirements
The successful applicant will possess a recent PhD in biological sciences with previous experience and demonstrated expertise through peer reviewed publications in one or more of the following: biochemical reconstitution and characterization of complex enzymatic reactions, structural biology and biophysical characterization of ligand-protein interactions, chemical biology, in vitro and in vivo cancer models, and functional genomics. Previous experience and expertise in ubiquitin and ubiquitin-like protein signaling or molecular aspects of cancer are desirable, but not necessary. We are seeking a self-motivated, enthusiastic, dedicated, and collaborative individual who is willing to be an essential part of a dynamic and fast-paced research environment. Applicants should submit their current CV, contact information for three referees, and a brief description of previous experience to petroski@sanfordburnham.org.
La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Position
Principal Investigator
Jing Crystal Zhao, Ph.D.
Research Description
We seek a highly motivated postdoctoral fellow to study the roles of RNA modification in stem cell biology and cancer development. mRNA and noncoding RNA modification, particularly methylation at the N6 position of adenosine (N6-methyladenosine), has emerged as an important research area in epigenetics and RNA biology. My lab identified a protein complex that governs N6-methyladenosine formation. We found such modification shortens the half-life of mRNAs, including developmental regulators, in mouse embryonic stem cells. Currently, we are digging deeper into the molecular mechanisms through which m6A regulates RNA activity, using a combination of biochemistry, cell biology, and high throughout sequencing technologies. Please refer to our recent publication for further information (Nature Cell Biology 16 (2): 191-8, Feb. 2014).

This position is expected to start in September 2014.
Requirements
Ph.D. and/or M.D. candidate with a background in biochemistry, molecular biology, cell biology, and/or animal models are encouraged to apply. Interested applicants should submit a CV, 3 reference letters, and a cover letter to czhao@sanfordburnham.org.

Cell Death and Survival Networks

La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Positions
Principal Investigator
Jorge Moscat, Ph.D.

Research Description
Two exciting postdoctoral positions in the laboratories of Drs. Moscat and Diaz-Meco, are available to study: (1) The role of metabolic reprogramming in the tumor stroma and its impact on cancer progression and metastasis; (2) The role and mechanisms of action of autophagy adapters and nutrient sensing in castration resistant prostate cancer.

Our goal is to identify potential new therapeutic targets for cancer treatment. Publications describing ongoing studies have appeared in for example: Mol. Cell 8, 771 (2001); Cell Metab. 3, 211 (2006); Mol. Cell 23, 631 (2006); Cancer Cell 13, 343 (2008); Cell 137, 1001 (2009); Cell Metab. 12, 65 (2010); Mol. Cell 44, 134 (2011); Cell 147, 724 (2011); Mol. Cell 44, 134 (2011); Mol. Cell 51, 283 (2013); Cell 152, 599 (2013). For more information about these labs and the work we are doing, please visit our web pages: http://www.sanfordburnham.org/Talent/Pages/JorgeMoscat.aspx
http://www.sanfordburnham.org/Talent/Pages/MariaDiaz-Meco.aspx

Requirements
We are looking for highly motivated and enthusiastic individuals who are interested in these very competitive topics, and with expertise in signal transduction and molecular and cellular techniques, as well as prior experience working with mouse models. Candidates must have a Ph.D. or M.D. degree and a publication record demonstrating expertise in at least some of the relevant areas. Interested applicants should submit a single PDF file containing CV, a brief description of research accomplishments, interests, and career goals, and contact information (e-mail address and phone number) of three references to Dr. Jorge Moscat c/o Maria T. Diaz-Meco at jmoscat@sanfordburnham.org.

Positions are available starting immediately. Salary will be determined by the successful candidate's skills and qualifications.

Tumor Microenvironment and Metastasis

La Jolla, CA
Postdoctoral Training Opportunity
Angiogenesis/Tumor Biology
Principal Investigator
William Stallcup, Ph.D.
Research Description
A postdoctoral position is available to study the function of the NG2 proteoglycan in both normal and tumor vascularization, building on the existing knowledge concerning NG2 participation in pericyte/endothelial cell interaction. A primary focus will be the investigation of NG2 function in mammary tumorigenesis, using both cell culture and animal models.
Requirements
Experience with relevant models, especially the use of histology and immunocytological imaging to study vivo mammary development and tumor progression, will be especially valuable. Expertise in areas such as cell biology, molecular biology, and biochemistry is also desirable. Candidates must have either a Ph.D. or M.D. and a publication record in one or more of the relevant areas. Interested applicants should submit a copy of their CV, and contact information (email address and phone number) of three references to: Dr. Bill Stallcup at stallcup@sanfordburnham.org.
La Jolla, CA
Postdoctoral Training Opportunity
VEGF Biology in Pathophysiological Conditions
Principal Investigator
Sunyoung Lee, Ph.D.
Research Description
A Postdoctoral position in vascular biology is available in Tumor Microenvironment and Metastasis program, Sanford-Burnham Medical Research Institute, La Jolla, CA. Sanford-Burnham has leading multi-disciplinary collaborative research groups, which is combining traditional developmental biology and molecular cell biology approaches with cutting-edge tools from chemistry, proteomics and engineering to develop entirely new approaches to cancer therapy. The current focuses in the lab include: to investigate the mechanism by which tumor microenvironment affects tumor angiogenesis and tumor progression, to study how vascular homeostasis is maintained and to study the interaction between vascular development and organogenesis.
Requirements
A recent Ph.D. or M.D/Ph.D. in molecular and cellular biology, cancer and developmental biology or biochemistry is required. Previous experience in animal work is highly desired. Good communication skills, organization skills, responsibility and an interactive team oriented attitude are also important factors. Interested applicants should submit a copy of their CV, a brief statement of research skills, and contact information (email address and phone number) of three references to: Dr. Sunyoung Lee at slee@sanfordburnham.org.
Lake Nona, FL
Postdoctoral Training Opportunity
Postdoctoral Associate
Principal Investigator
Masanobu Komatsu, Ph.D.
Program Name
Tumor Microenvironment and Metastasis and Cardiovascular Pathobiology.
Research Description
A postdoctoral position is available to investigate the regulatory mechanism of blood vessel maturation and stabilization. Our laboratory has shown that the small GTPase R-Ras promotes quiescence of vascular cells and normalizes newly forming vessels in the pathologically regenerating vasculature (Nature Medicine 2005, Cancer Cell 2012). The goal of this study is to exploit the R-Ras pathways in order to modulate blood vessels for therapeutic advantage, for instance 1) to block metastasis and improve drug delivery in cancer, or 2) to improve blood perfusion in ischemic heart disease. Prospective candidates will be conducting this study at our Florida campus in Orlando. Visit our website for research focuses of the laboratory.
Requirements
The ideal candidates will have expertise in signal transduction, cancer and/or vascular biology, transgenic models, in vivo and cell imaging techniques. Candidates must be highly self-motivated, independent individuals with M.D. or Ph.D. and hold publication records in one or more of the relevant areas. Interested applicants should submit a single PDF file containing CV, a brief description of research interests and accomplishments to Dr. Komatsu. mkomatsu@sanfordburnham.org

Immunity and Pathogenesis

La Jolla, CA
Postdoctoral Training Opportunity
Molecular Virology
Principal Investigator
Sumit Chanda, Ph.D.
Research Description
A postdoctoral position is immediately available in the Infectious and Inflammatory Disease Center (IIDC) in the laboratory of Dr. Sumit K. Chanda as part of a multi-disciplinary program grant focused on generating a systems-level understanding of innate immunology/pattern recognition receptor responses and virus-host interactions. This position will be focused on defining molecular mechanisms of certain innate immune signaling pathways in the context of pathogen infection using systems-based approaches. Studies will integrate both large-scale technologies (RNAi, AP-MS, NextGen Sequencing, etc.) and more traditional cell & molecular biology and biochemistry-based approaches. Positions are supported by NIH funding.
Requirements
Highly motivated candidates who recently obtained a Ph.D., with a strong background in immunology, virology, cell biology, and biochemistry are encouraged to apply. In addition, experience in innate immune signaling and an understanding and ability to apply statistical techniques to the analysis of large data sets are a plus. Candidates must have good communication skills, and should be able to work independently and in a collaborative scientific environment. Successful candidates will have a strong publication record in peer-reviewed journals.

Interested individuals should send their curriculum vitae, a brief description of their research interests, and the names of three references to: Crystal Herndon at cherndon@sanfordburnham.org. Please visit www.chandalab.org for additional information.

Human Genetics

La Jolla, CA
Postdoctoral Training Opportunities
Human Glycosylation Disorders
Principal Investigator
Hudson Freeze, Ph.D.
Research Description
We have several postdoctoral positions that involve human genetic disorders. The first position identifies and documents new human Congenital Disorders of Glycosylation (CDG) among our patients analyzed by whole exome sequencing. Validating pathological mutations requires design of quantitative biochemical and cell biological assays. Some newly discovered genes involve nucleotide sugar metabolism, control of metabolic flux, sugar transport, and characterization of potential therapeutics in various patient-derived cells lines.

Another exciting project launches an unbiased search for new genes that cause glycosylation disorders. The approach screens for surviving HAP-1 cells based on high throughput analysis.

A third position is available to study the fundamental cellular pathology in patients with deficiencies in NGLY1, the enzyme responsible for cleaving N-glycans from misfolded glycoproteins retro-translocated into the cytoplasm. This project requires knowledge of glycobiology and ERAD-related issues.
Requirements
Solid background and dexterity is expected in standard molecular, biochemical and cell biology methods using mammalian cells. Experience in fluoresence microscopy, glycobiology background, and metabolomic analysis is required in some projects. For others, hands-on yeast genetics experience is needed or 96-well screening methods. Familiarity with state of the art informatic analysis of DNA sequencing results is needed.

Fluent spoken English, along with an interactive, cooperative attitude plus a willingness to interact with and help patients is a must.

Interested applicants should submit a copy of their CV and contact information (email address and phone number) of three references to: Dr. Hudson Freeze at hudson@sanfordburnham.org.
La Jolla, CA

Postdoctoral Training Opportunity

Development and Disease

Principal Investigator
Duties and Responsibilities
We seek individuals who are rigorous, productive, full of curiosity, have a persistent will to solve problems, always seeking new ideas and concepts, have effective communication skills, and who works well with others. The PI is devoted rigorous science and mentoring, emphasizing research philosophy and career advancement. Available projects range from basic developmental mechanisms and progenitor cell fate regulation, to modeling diseases, to genetic/chemical screens, and to in vivo genetic/chemical cell fate reprograming, and/or create your own projects. Please see our lab website.
Requirements
Postdoctoral candidates should have a Ph.D. or an M.D. with a solid background in molecular biology, development and genetics, or cell biology/biochemistry and at least one senior author publication. -omics experience is a plus.

Development, Aging, and Regeneration

La Jolla, CA
Postdoctoral Training Opportunity
Analysis of Cardiac Genes
Principal Investigator
Rolf Bodmer, Ph.D.
Research Description
A Postdoctoral position is available for a candidate to study the genetic control of the heart, using primarily Drosophila as a model system. Possible projects using molecular-genetic, imaging and physiological techniques range from analysis of early cardiogenic genes to genes controlling heart function and cardiac aging to genes involved in left-right asymmetry.
Requirements
Candidates must have a Ph.D. Interested applicants should submit a copy of their CV and contact information (email address and phone number) of three references to: Dr. Rolf Bodmer at rolf@sanfordburnham.org.
La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Position
Principal Investigator
Alexey Terskikh, Ph.D.
Research Description
Postdoctoral positions are available to research and study comprehensive functional analysis of neural stem cells and their niches using a model of adult hippocampal neurogenesis. The candidate should be familiar with animal handling, tissue preparation and immunofluorescent analysis and have molecular and cellular biology skills. Our research is aimed at elucidating fundamental mechanisms that regulate adult hippocampal neurogenesis.
Requirements
Candidates must have a Ph.D. or M.D. in a relevant discipline along with demonstrated experience in the area of proposed research. Interested applicants should submit a copy of their CV and a list of at least three professional references to: Dr. Alexey Terskikh at terskikh@sanfordburnham.org.
La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Position
Principal Investigator
Alexey Terskikh, Ph.D.
Research Description
Postdoctoral positions are available to research and study MELK function in tumorigensis using genetic (mouse) models of glioblastoma and primary human GBM lines. The candidate should have strong background in cancer (preferably brain tumors) and have molecular and cellular biology skills. Our research is focused on studying cellular and molecular mechanisms of tumorigenesis, in particular with respect to the cancer stem cell hypothesis.
Requirements
Candidates must have a Ph.D. or M.D. in a relevant discipline along with demonstrated experience in the area of proposed research. Interested applicants should submit a copy of their CV and a list of at least three professional references to: Dr. Alexey Terskikh at terskikh@sanfordburnham.org.
La Jolla, CA
Postdoctoral Training Opportunity
Development and Disease
Principal Investigator
Duties and Responsibilities
We seek individuals who are rigorous, productive, full of curiosity, have a persistent will to solve problems, always seeking new ideas and concepts, have effective communication skills, and who works well with others. The PI is devoted rigorous science and mentoring, emphasizing research philosophy and career advancement. Available projects range from basic developmental mechanisms and progenitor cell fate regulation, to modeling diseases, to genetic/chemical screens, and to in vivo genetic/chemical cell fate reprograming, and/or create your own projects. Please see our lab website.
Requirements
Postdoctoral candidates should have a Ph.D. or an M.D. with a solid background in molecular biology, development and genetics, or cell biology/biochemistry and at least one senior author publication. -omics experience is a plus.

Bioinformatics and Structural Biology

La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Position
Principal Investigator
Niels Volkmann, Ph.D.
Research Description
A postdoctoral position is immediately available in the laboratory of Dr. Niels Volkmann, Sanford-Burnham Medical Research Institute (SBMRI), located on the Torrey Mesa in La Jolla, walking distance from Salk, Scripps, and UCSD (La Jolla, CA, USA).

Our research focuses on the development and application of approaches for structure determination of small and structurally heterogeneous macromolecules by cryo-EM (many of them helical) as well as for reconstruction and interpretation of cellular tomograms obtained by cryo-electron tomography. All work will be conducted in close collaboration with Dr. Dorit Hanein’s experimental cryo-EM group at SBMRI.
Requirements
The successful candidate should be highly motivated and have a PhD in structural biology, image processing or a related subject, good communication skills and a strong analytical mind. Preference will be given to experts in algorithm design and scientific computer programming with a proven interest in structural biology and to candidates who have excellent skills in experimental cryo-EM and application of structure determination approaches such as single-particle, helical, or tomographic reconstruction methods.

Candidates should send a CV, statement of research interest and focus, and provide the contact information for at least three professional references to Dr. Niels Volkmann, niels@sanfordburnham.org.

Cardiovascular Pathobiology

There are no postdoctoral training opportunities in this program at this time.
Lake Nona, FL
Postdoctoral Associate
Dr. Layton H. Smith
Cardiovascular Pathobiology
A post-doctoral position is available to study mechanisms by which the peptide hormone apelin and its receptor influence cardiovascular and metabolic homeostasis.  The laboratory currently has two extramurally funded projects in this area: 1) identification of signaling pathways underlying the pro-angiogenic effects of apelin and 2) development of apelin receptor antagonists for therapeutic applications. Post-doctoral research will include experimental design and execution, and interpretation of results obtained using various in vitro assays with the goal of defining the molecular pathways regulated by apelin, as well as characterizing the pharmacology and mechanism of action of novel small molecule antagonists of the apelin receptor. These projects combine state-of-the-art approaches for determining receptor pharmacology, and mechanistic studies using molecular biology and cell-based assays.  It is anticipated that the successful post-doctoral research associate will interface with the broader research group to advance related projects within the group.
Sanford-Burnham Medical Research Institute at Lake Nona (Orlando) is an independent, not-for-profit biomedical research institution dedicated to advancing the frontiers of scientific knowledge in life sciences and medicine with an emphasis on research on Diabetes and Obesity.  The Lake Nona/Orlando site has several outstanding technology cores for modern molecular and chemical biology research, with a strong interdisciplinary collaborative approach to scientific study.  There are also opportunities for clinical/translational studies via a strong collaborative interaction between the Sanford-Burnham Lake Nona site and the Translational Research Institute for Metabolism and Diabetes at the Florida Hospital.
Candidates must have a Ph.D. and/or M.D. and a strong background in one of the following areas: vascular biology, cell/molecular biology, pharmacology.  Experience with transgenic mouse models, and/or in vitro and in vivo angiogenesis assays is a plus.  It is important that the candidate have excellent communication and interpersonal skills and the ability to work within an interdisciplinary team. 
Interested applicants should submit a cover letter indicating research accomplishments and interests, CV, and contact information for at least 3 references as a single PDF or Word document to: sarah@sanfordburnham.org

Metabolic Disease

Lake Nona, FL
Postdoctoral Training Opportunity
Postdoctoral Associate
Principal Investigator
Timothy Osborne, Ph.D.
Program Name
Metabolic Disease
Research Description
A Postdoctoral Associate position is available to study immune system regulation of mammalian lipid metabolism through cellular, molecular and genetic mechanisms.

Sanford-Burnham Medical Research Institute at Lake Nona (Orlando) is an independent, not-for-profit biomedical research institution dedicated to advancing the frontiers of scientific knowledge in life sciences and medicine with an emphasis on research on Diabetes and Obesity. Sanford-Burnham has recently finished building 175,000 sq.ft. state-of-the-art laboratory facilities for over 300 faculty and staff. The Lake Nona/Orlando site has several outstanding technology cores for modern molecular and metabolic research, with a strong interdisciplinary collaborative approach to scientific study.
Requirements
Candidates must have a Ph.D. and or M.D. and must have a strong background in technical skills in the following areas: mouse metabolism and inflammation including immunological methods such as immune cell isolation, phagocytosis, apoptosis, cytokine analysis, flow cytometry and immunohistochemistry as well as strong molecular and cell biology skills. Interested applicants should submit a cover letter including research accomplishments and interests, CV and names of at least three (3) references to pphelan@sanfordburnahm.org
Lake Nona, FL
Postdoctoral Training Opportunity
Postdoctoral Associate
Principal Investigator
Timothy Osborne, Ph.D.
Research Description
Postdoctoral Associate position available to study the regulation of intestinal nutrient absorption, gut endocrine signaling, and gastrointestinal physiology through cellular, molecular, and genetic mechanisms.

Sanford-Burnham Medical Research Institute at Lake Nona (Orlando) is an independent, not-for-profit biomedical research institution dedicated to advancing the frontiers of scientific knowledge in life sciences and medicine with an emphasis on research on Diabetes and Obesity. Sanford-Burnham has recently finished building 175,000 sq.ft. state-of-the-art laboratory facilities for over 300 faculty and staff. The Lake Nona/Orlando site has several outstanding technology cores for modern molecular and metabolic research, with a strong interdisciplinary collaborative approach to scientific study.
Requirements
Candidates must have a Ph.D. and/or M.D. and must have a strong background in molecular skills associated with intestinal endocrine cell analysis and function as well as in the following technical areas: maintenance and manipulation of mouse genetic models, immunohistochemistry, as well as molecular and cell biology skills. Interested applicants should submit a cover letter including research accomplishments and interests, CV, and names of at least 3 references to pphelan@sanfordburnham.org.
Lake Nona, FL
Postdoctoral Training Opportunity
Postdoctoral Associate
Principal Investigator
Julio Ayala, Ph.D.
Program Name
Metabolic Disease
Research Description
A postdoctoral position is available to study mechanisms by which the incretin hormone glucagon-like peptide-1 (Glp1) regulates energy balance via the Glp1 receptor (Glp1r) in the central nervous system.  The laboratory currently has two extramurally funded projects in this area: 1) identification of hypothalamic signaling mechanisms modulated by Glp1r agonists in response to diets of different carbohydrate composition and 2) assessing the potential role of biased signaling via the Glp1r in the regulation of food intake by different Glp1r agonists.  These projects combine state-of-the-art approaches for the measurement of energy balance in transgenic mouse models and mechanistic studies using molecular biology and cell-based assays. 

Sanford-Burnham Medical Research Institute at Lake Nona (Orlando) is an independent, not-for-profit biomedical research institution dedicated to advancing the frontiers of scientific knowledge in life sciences and medicine with an emphasis on research on Diabetes and Obesity.  The Lake Nona/Orlando site has several outstanding technology cores for modern molecular and metabolic research, with a strong interdisciplinary collaborative approach to scientific study.  There are also opportunities for clinical/translational studies via a strong collaborative interaction between the Sanford-Burnham Lake Nona site and the Translational Research Institute for Metabolism and Diabetes at the Florida Hospital.
Requirements
Candidates must have a Ph.D. and/or M.D. and a strong background in one of the following areas: physiology, metabolism, cell/molecular biology, pharmacology.  Experience with transgenic mouse models is a plus.  It is important that the candidate have excellent communication and interpersonal skills and the ability to work within an interdisciplinary team. 
 
Interested applicants should submit a cover letter indicating research accomplishments and interests, CV, and contact information for at least 3 references as a single PDF or Word document to: jayala@sanfordburnham.org

Genomic Control of Metabolism

There are no postdoctoral training opportunities in this program at this time.

Conrad Prebys Center for Chemical Genomics

There are no postdoctoral training opportunities in this center at this time.
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