Current Postdoctoral Training Opportunities

Current Postdoctoral Training Opportunities

Tumor Initiation and Maintenance

La Jolla, CA
Postdoctoral Training Opportunity
Organic Chemist
Principal Investigator
Marcia Dawson, Ph.D.
Research Description
A Postdoctoral position is available in Synthetic Organic Chemistry.
Requirements
Candidates must have a Ph.D. and be experienced in multi-step natural product synthesis and characterization. Must be self-motivated and able to communicate effectively both orally and written. Interested applicants should submit a copy of their CV to: Dr. Marcia Dawson at mdawson@sanfordburnham.org.
La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Position
Principal Investigator
Charles Spruck, Ph.D.
Research Description
A Postdoctoral position is available to work on various projects that will explore the molecular regulations of cell division control and define how alterations of these processes contribute to cancer development and progression. An emphasis of these projects will be the ubiquitin proteasome system (UPS) and the role of protein destruction in cancer.
Requirements
Candidates must have a Ph.D. and have a strong background in molecular biology techniques. Experience in the fields of DNA damage response and ubiquitin-dependent proteolysis are preferred, but not required. Interested applicants should submit a copy of their CV and a list of at least three professional references to: Dr. Charles Spruck at cspruck@sanfordburnham.org.
La Jolla, CA
Postdoctoral Training Opportunity
Principal Investigator
Matthew Petroski, Ph.D.
Research Description
A postdoctoral position is available in the laboratory of Matthew Petroski, Ph.D. within the Tumor Initiation and Maintenance Program of the NCI-designated Cancer Center at Sanford-Burnham Medical Research Institute in La Jolla, California. Our research focuses on understanding the functions and regulation of ubiquitin and ubiquitin-like proteins. A major emphasis is on identifying and characterizing targets of ubiquitin and ubiquitin-like protein post-translational modification systems for developing therapeutics for diseases such as cancer.
Requirements
The successful applicant will possess a recent PhD in biological sciences with previous experience and demonstrated expertise through peer reviewed publications in one or more of the following: biochemical reconstitution and characterization of complex enzymatic reactions, structural biology and biophysical characterization of ligand-protein interactions, chemical biology, in vitro and in vivo cancer models, and functional genomics. Previous experience and expertise in ubiquitin and ubiquitin-like protein signaling or molecular aspects of cancer are desirable, but not necessary. We are seeking a self-motivated, enthusiastic, dedicated, and collaborative individual who is willing to be an essential part of a dynamic and fast-paced research environment. Applicants should submit their current CV, contact information for three referees, and a brief description of previous experience to petroski@sanfordburnham.org.
La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Position
Principal Investigator
Jing Crystal Zhao, Ph.D.
Research Description
We seek a highly motivated postdoctoral fellow to study the roles of RNA modification in stem cell biology and cancer development. mRNA and noncoding RNA modification, particularly methylation at the N6 position of adenosine (N6-methyladenosine), has emerged as an important research area in epigenetics and RNA biology. My lab identified a protein complex that governs N6-methyladenosine formation. We found such modification shortens the half-life of mRNAs, including developmental regulators, in mouse embryonic stem cells. Currently, we are digging deeper into the molecular mechanisms through which m6A regulates RNA activity, using a combination of biochemistry, cell biology, and high throughout sequencing technologies. Please refer to our recent publication for further information (Nature Cell Biology 16 (2): 191-8, Feb. 2014).

This position is expected to start in September 2014.
Requirements
Ph.D. and/or M.D. candidate with a background in biochemistry, molecular biology, cell biology, and/or animal models are encouraged to apply. Interested applicants should submit a CV, 3 reference letters, and a cover letter to czhao@sanfordburnham.org.

Cell Death and Survival Networks

La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Positions
Principal Investigator
Jorge Moscat, Ph.D.

One exciting postdoctoral position in the laboratory of Dr. Jorge Moscat is available to study the role of metabolic reprograming in the tumor stroma and its impact on cancer progression and metastasis in liver tumors.

Our goal is to identify potential new therapeutic targets for cancer treatment. Publications describing ongoing studies have appeared in for example: Mol. Cell (2011, 2013) Cell Metab. (2006, 2011, 2014); Cancer Cell (2008, 2014); Cell (2009, 2011, 2013)
For more information about the Moscat lab and the work we are doing, please visit http://www.sanfordburnham.org/Talent/Pages/JorgeMoscat.aspx

Requirements
We are looking for highly motivated and enthusiastic individuals who are interested in these very competitive topics, and with expertise in signal transduction and molecular and cellular techniques, as well as prior experience working with mouse models. Candidates must have a Ph.D. or M.D. degree and a publication record demonstrating expertise in at least some of the relevant areas. International applicants must hold a fellowship to support at least part of their salary at the time of joining the lab. Interested applicants should submit a single PDF file containing CV, a brief description of research accomplishments, interests, and career goals, and contact information (e-mail address and phone number) of three references to Dr. Jorge Moscat at jmoscat@sanfordburnham.org.

Positions are available starting immediately.

La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Positions
Principal Investigator
Cosimo Commisso, Ph.D.

Research Description
The Cell Death and Survival Networks Program of Sanford-Burnham Medical Research Institute located in La Jolla, CA, is recruiting a Postdoctoral Fellow to study cancer cell biology and tumor metabolism.

The Commisso Lab (www.commissolab.com) is focused on biological discoveries that have the potential to lead to novel therapeutic strategies for cancer. Of particular interest to our laboratory are Ras-driven cancers, such as pancreatic cancer, which are extremely aggressive and are in urgent need of new and innovative therapies. The biological process that we study in the lab is called macropinocytosis, a fluid-phase form of bulk endocytic uptake, which we have linked to cancer cell metabolism in Ras-mutated tumors.

We are seeking a highly motivated individual to join our research team. The successful candidate will be an active participant in a vibrant, collaborative atmosphere. The candidate will design and implement experiments using a variety of techniques such as cell culture, cell biology, molecular biology, and animal tumor models to help understand cancer cell metabolic dependencies at the molecular level. The main goal is to identify and develop novel therapeutic targets and to discover therapeutic agents to treat Ras-driven cancers.

Requirements
Experimental bench science is an essential requirement, as well as the ability to present and discuss data. A research background in cancer biology, cell biology, biochemistry or developmental biology is preferred and prior experience with mouse models, cell signaling, and/or microscopy would be an asset.

Candidates must have a Ph.D. degree and demonstrate the ability to successfully spearhead a research project.

Interested applicants should submit a cover letter and a CV. The last page of the CV should include the contact information (e-mail address and phone number) for three references. The PDF files should be emailed to Dr. Cosimo Commisso at ccommisso@sanfordburnham.org.

Positions are available starting immediately. Sanford-Burnham Medical Research Institute offers generous benefits as an important part of our total rewards package designed to support the physical, emotional and financial health and well-being of our diverse workforce. Competitive salary will be offered and determined by the successful candidate's skills and qualifications.

Tumor Microenvironment and Metastasis

La Jolla, CA
Postdoctoral Training Opportunity
Angiogenesis/Tumor Biology
Principal Investigator
William Stallcup, Ph.D.
Research Description
A postdoctoral position is available to study the function of the NG2 proteoglycan in both normal and tumor vascularization, building on the existing knowledge concerning NG2 participation in pericyte/endothelial cell interaction. A primary focus will be the investigation of NG2 function in mammary tumorigenesis, using both cell culture and animal models.
Requirements
Experience with relevant models, especially the use of histology and immunocytological imaging to study vivo mammary development and tumor progression, will be especially valuable. Expertise in areas such as cell biology, molecular biology, and biochemistry is also desirable. Candidates must have either a Ph.D. or M.D. and a publication record in one or more of the relevant areas. Interested applicants should submit a copy of their CV, and contact information (email address and phone number) of three references to: Dr. Bill Stallcup at stallcup@sanfordburnham.org.
La Jolla, CA
Postdoctoral Training Opportunity
VEGF Biology in Pathophysiological Conditions
Principal Investigator
Sunyoung Lee, Ph.D.
Research Description
A Postdoctoral position in vascular biology is available in Tumor Microenvironment and Metastasis program, Sanford-Burnham Medical Research Institute, La Jolla, CA. Sanford-Burnham has leading multi-disciplinary collaborative research groups, which is combining traditional developmental biology and molecular cell biology approaches with cutting-edge tools from chemistry, proteomics and engineering to develop entirely new approaches to cancer therapy. The current focuses in the lab include: to investigate the mechanism by which tumor microenvironment affects tumor angiogenesis and tumor progression, to study how vascular homeostasis is maintained and to study the interaction between vascular development and organogenesis.
Requirements
A recent Ph.D. or M.D/Ph.D. in molecular and cellular biology, cancer and developmental biology or biochemistry is required. Previous experience in animal work is highly desired. Good communication skills, organization skills, responsibility and an interactive team oriented attitude are also important factors. Interested applicants should submit a copy of their CV, a brief statement of research skills, and contact information (email address and phone number) of three references to: Dr. Sunyoung Lee at slee@sanfordburnham.org.
Lake Nona, FL
Postdoctoral Training Opportunity
Postdoctoral Positions
Principal Investigator
Masanobu Komatsu, Ph.D.
Research Description
Postdoctoral positions are available in two related fields. The first is to investigate the regulatory mechanism of blood vessel maturation and stabilization. Our laboratory has shown that the small GTPase R-Ras promotes quiescence of vascular cells and normalizes newly forming vessels in the pathologically regenerating vasculature (Nature Medicine 2005, Cancer Cell 2012). The goal of this study is to exploit the R-Ras pathways in order to modulate blood vessels for therapeutic advantage, for instance 1) to block metastasis and improve drug delivery in cancer, or 2) to improve blood perfusion in ischemic heart disease.

The other area of research focus is to develop novel drug delivery technologies using peptide-directed vascular targeting. We have worked primarily on targeting tumors, organ fibrosis, and pulmonary arterial hypertension for delivery of therapeutics and imaging probes (American Journal of Pathology 2010 and 2014, Biomaterials 2012). In particular, we pioneered the method to target pulmonary arterial hypertension for lung-specific delivery of therapeutics.

Prospective candidates will be conducting these studies at our Florida campus in Orlando. Visit our website for more information on research focuses of the laboratory.
Requirements
The ideal candidates will have expertise in signal transduction, cancer and/or vascular biology, transgenic models, in vivo and cell imaging techniques, and/or drug delivery. Candidates must be highly self-motivated, independent individuals with M.D. or Ph.D. and hold publication records in one or more of the relevant areas. Interested applicants should submit a single PDF file containing CV, a brief description of research interests and accomplishments to Dr. Komatsu at mkomatsu@sanfordburnham.org

Degenerative Diseases

La Jolla, CA
Postdoctoral Training Opportunity
Cell and Molecular Biology of Alzheimer's Disease
Principal Investigator
Huaxi Xu, Ph.D.
Research Description
A Postdoctoral position is available to study molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease. Our research projects involve proteolytic processing and trafficking of beta-amyloid precursor protein, regulation of beta-amyloid generation and tau phosphorylation, and identification of novel genes and genetic pathways affecting beta-amyloid metabolism.
Requirements
Candidates must have a Ph.D. Outstanding candidates with expertise in cell and molecular biology are sought. Applicants with recent doctoral degrees should send their curriculum vitae contact information (email address and phone number) of three references to: Dr. Huaxi Xu at xuh@sanfordburnham.org.
La Jolla, CA
Postdoctoral Training Opportunity
Principal Investigator
Dongxian Zhang, Ph.D.
Research Description
A postdoctoral position is available to study novel ligands specific for ionotropic glutamate receptors, aimed at developing drugs in treating brain disorders in cell culture and animal models. The candidate should be familiar with electrophysiological approaches using the in vitro preparations. Experience in analysis of protein-ligand interaction using biochemical and molecular biological approaches are a plus.
Requirements
Candidates with a recent Ph.D. along with demonstrated experience in the area of proposed research should send their curriculum vitae and contact information for three professional references to: Dr. Zhang at dzhang@sanfordburnam.org.
La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Position
Principal Investigator
Research Description
The laboratory of Dr. Randal Kaufman at Sanford-Burnham Medical Research Institute in La Jolla, California has an opening for a Postdoctoral Associate. The lab’s research is aimed at elucidating fundamental mechanisms that regulate protein folding and the cellular responses to the accumulation of unfolded protein within the endoplasmic reticulum. Various projects are available including studies directed to elucidate the molecular logic for the UPR adaptive response in the hopes of providing fundamental insight into numerous pathological conditions such as viral infection, cancer, inflammation, metabolic disease and atherosclerosis, and protein folding diseases such as Parkinsons disease and Alzheimers disease.
Requirements
Candidates for this position must have a PhD or MD. A strong publication record, excellent communication skills and ability to work in a team are essential. Experience in working with genetically engineered mice is a plus. Technical skills will include molecular and cellular biology, protein biochemistry, and murine genetics.
 
Interested applicants should submit a copy of their CV, contact information (email address and phone number) of three references, and a brief statement of research skills and interest to: Dr. Randal Kaufman c/o Taryn Goode: tgoode@sanfordburnham.org.
La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Position
Principal Investigator
Randal Kaufman, Ph.D.
Program
Degenerative Diseases

Research Description
The laboratory of Dr. Randal J. Kaufman at the Sanford-Burnham Medical Research Institute in La Jolla, California has an opening for a Postdoctoral Associate to work on the progression of fatty liver disease to non-alcoholic steatohepatitis and hepatocellular carcinoma.  Due to the obesity epidemic, this is expected to be a major focus for future research for years to come.
 
The lab’s research is aimed at elucidating fundamental mechanisms that regulate protein folding and the cellular responses to the accumulation of unfolded protein within the endoplasmic reticulum. Of most significance are recent discoveries regarding how protein misfolding impacts liver failure and development of non-alcoholic steatohepatitis and eventually hepatocellular carcinoma.  The lab has unique mouse models to answer questions that are not possible anywhere else in the world. Technologies will include liver physiology/pathology, especially lipid metabolism and inflammation. The lab uses the most sophisticated technologies including mRNA-Seq, high throughput small molecule/siRNA screening, mass spectrometry, electron microscopy and the most advanced methods of manipulating the murine genome.  The position requires working with mice, isolating liver for RNA, protein and lipid analysis and isolation/characterization of primary hepatocytes. The preferred candidate should have strong background in molecular and cellular biology, biochemistry and physiology.

Requirements
Candidates for this position must have a Ph.D. or M.D.
 
A strong publication record, excellent communication skills and ability to work in a team are essential. Experience in working with mice is a plus. This is a truly unique position to work on a high profile project that will have impact on human medical care.
 
Interested applicants should submit a copy of their CV, contact information (email address and phone number) of three references, and a brief statement of research skills and interest to: Dr. Randal Kaufman c/o Taryn Goode: tgoode@sanfordburnham.org.
 
Relevant Publications:
 
Nakagawa, et al. (2014) ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development. Cancer Cell26(3): 331-343.
 
Han et al. (2013) Endoplasmic reticulum (ER) stress-induced transcriptional regulation increases protein synthesis leading to cell death. Nature Cell Biol. 15(5): 481-90. PMC3692270.
 
Wang et al. (2012) IRE1α-XBP1s induces PDI expression to increase MTP activity forhepatic VLDL assembly and lipid homeostasis. Cell Metabolism16(4): 473-86. PMC3569089
 
 
 

Immunity and Pathogenesis

La Jolla, CA
Postdoctoral Training Opportunity
Molecular Virology
Principal Investigator
Sumit Chanda, Ph.D.
Research Description
A postdoctoral position is immediately available in the Infectious and Inflammatory Disease Center (IIDC) in the laboratory of Dr. Sumit K. Chanda as part of a multi-disciplinary program grant focused on generating a systems-level understanding of innate immunology/pattern recognition receptor responses and virus-host interactions. This position will be focused on defining molecular mechanisms of certain innate immune signaling pathways in the context of pathogen infection using systems-based approaches. Studies will integrate both large-scale technologies (RNAi, AP-MS, NextGen Sequencing, etc.) and more traditional cell & molecular biology and biochemistry-based approaches. Positions are supported by NIH funding.
Requirements
Highly motivated candidates who recently obtained a Ph.D., with a strong background in immunology, virology, cell biology, and biochemistry are encouraged to apply. In addition, experience in innate immune signaling and an understanding and ability to apply statistical techniques to the analysis of large data sets are a plus. Candidates must have good communication skills, and should be able to work independently and in a collaborative scientific environment. Successful candidates will have a strong publication record in peer-reviewed journals.

Interested individuals should send their curriculum vitae, a brief description of their research interests, and the names of three references to: Crystal Herndon at cherndon@sanfordburnham.org. Please visit www.chandalab.org for additional information.
La Jolla, CA
Postdoctoral Training Opportunities
Host-Pathogen Interactions at Mucosal Surfaces
Principal Investigator
Bas Baaten, Ph.D.
Research Description
A postdoctoral position is immediately available in the immunity and pathogenesis program at the Sanford-Burnham Medical Research Institute to study host-pathogen interactions at mucosal surfaces. The selected candidate will lead our ongoing efforts to identify the mechanisms that govern the balance between immunity and pathology at the nasal and pulmonary mucosa following viral infection.

Current projects are focused on exploring the mechanisms underlying defective T cell immunity in the aged following influenza virus infection. He/she will use an array of cellular and molecular approaches to evaluate immune function in mouse models and human cells and is expected to formulate, execute, and communicate research projects.
Requirements
Highly motivated individuals with a strong background in cellular and molecular immunology and who recently obtained a Ph.D. are strongly encouraged to apply. Previous experience with mouse models is highly desired. Candidates must have good communication skills, and should be able to work independently and in a collaborative scientific environment.

Interested applicants should submit a CV, contact information (e-mail address and phone number) of three references, and a brief description of research accomplishments, interests, and career goals to bbaaten@sanfordburnham.org.
La Jolla, CA
Postdoctoral Training Opportunities
Molecular Virology
Principal Investigator
Sumit Chanda, Ph.D.
Program
Immunity and Pathogenesis Program
Research Description
Multiple postdoctoral positions are immediately available in Sanford Burnham Medical Research Institute’s Infectious and Inflammatory Disease Center (IIDC) in the laboratory of Dr. Sumit K. Chanda.  Positions will focus on generating a systems-level understanding of immune responses pathways including TLRs, cGAS, CD40 and Fc-mediated signaling.  Prospective candidates will play an important role in elucidating novel factors involved in the interplay between host innate immune factors and their implication in inflammatory and autoimmune disease.  Aspects of certain projects will involve collaborations with Pharma R&D teams.
Requirements
Highly motivated candidates who recently obtained a Ph.D., with a strong background in innate immune signaling are encouraged to apply.   The ideal candidate will have a deep understanding of the innate immune system including TLR, NLR, and RLR signaling as well as pathways induced in  myeloid & B cells.  In addition, experience in virology, cell biology, and biochemistry and an understanding and ability to apply statistical techniques to the analysis of large data sets are a plus. Candidates must have good communication skills, and should be able to work independently and in a collaborative scientific environment.  Successful candidates will have a strong publication record in peer-reviewed journals. 
Interested individuals should send their curriculum vitae, a brief description of their research interests, and the names of three references to:  Crystal Herndon at cherndon@sanfordburnham.org. Please visit [www.chandalab.org] for additional information.

Human Genetics

La Jolla, CA
Postdoctoral Training Opportunities
Human Glycosylation Disorders
Principal Investigator
Hudson Freeze, Ph.D.
Research Description
We have several postdoctoral positions that involve human genetic disorders. The first position identifies and documents new human Congenital Disorders of Glycosylation (CDG) among our patients analyzed by whole exome sequencing. Validating pathological mutations requires design of quantitative biochemical and cell biological assays. Some newly discovered genes involve nucleotide sugar metabolism, control of metabolic flux, sugar transport, and characterization of potential therapeutics in various patient-derived cells lines.

Another exciting project launches an unbiased search for new genes that cause glycosylation disorders. The approach screens for surviving HAP-1 cells based on high throughput analysis.

A third position is available to study the fundamental cellular pathology in patients with deficiencies in NGLY1, the enzyme responsible for cleaving N-glycans from misfolded glycoproteins retro-translocated into the cytoplasm. This project requires knowledge of glycobiology and ERAD-related issues.
Requirements
Solid background and dexterity is expected in standard molecular, biochemical and cell biology methods using mammalian cells. Experience in fluoresence microscopy, glycobiology background, and metabolomic analysis is required in some projects. For others, hands-on yeast genetics experience is needed or 96-well screening methods. Familiarity with state of the art informatic analysis of DNA sequencing results is needed.

Fluent spoken English, along with an interactive, cooperative attitude plus a willingness to interact with and help patients is a must.

Interested applicants should submit a copy of their CV and contact information (email address and phone number) of three references to: Dr. Hudson Freeze at hudson@sanfordburnham.org.
La Jolla, CA

Postdoctoral Training Opportunity

Principal Investigator
Research Description
We seek individuals who are rigorous, productive, full of curiosity, have a persistent will to solve problems, always seeking new ideas and concepts, have effective communication skills, and who works well with others. The PI is devoted rigorous science and mentoring, emphasizing research philosophy and career advancement. Available projects range from basic developmental mechanisms and progenitor cell fate regulation, to modeling diseases, to genetic/chemical screens, and to in vivo genetic/chemical cell fate reprograming, and/or create your own projects. Please see our lab website.
Requirements
Postdoctoral candidates should have a Ph.D. or an M.D. with a solid background in molecular biology, development and genetics, or cell biology/biochemistry and at least one senior author publication. -omics experience is a plus.
La Jolla, CA
Postdoctoral Training Opportunities
Principal Investigator
Hudson Freeze, Ph.D.
Program
Human Genetics

Research Description

NGLY1 mutations cause a human neurological disease of protein de-glycosylation. Pathological mechanisms are unknown

Requirements

This position requires significant publications in biochemistry, cell biology, glycobiology, ERAD or cytoplasmic protein degradation. Fluent spoken and written English, independent thinking, and team spirit are essential.
 
To respond, please send a single PDF document that includes all of the following: your current CV; a 2 page letter outlining your background, specific interest in NGLY1, and how you would study it; and 3 reference letters discussing your specific qualifications for this project.  Only those applicants who apply in this manner will be considered.
 
Please submit application materials to: azimmon@sanfordburnham.org
 
If interested in a challenging postdoctoral research opportunity in NGLY1, please read PMID: 24651605 and http://www.newyorker.com/magazine/2014/07/21/one-of-a-kind-2
 

Development, Aging, and Regeneration

La Jolla, CA
Postdoctoral Training Opportunity
Analysis of Cardiac Genes
Principal Investigator
Rolf Bodmer, Ph.D.
Research Description
A Postdoctoral position is available for a candidate to study the genetic control of the heart, using primarily Drosophila as a model system. Possible projects using molecular-genetic, imaging and physiological techniques range from analysis of early cardiogenic genes to genes controlling heart function and cardiac aging to genes involved in left-right asymmetry.
Requirements
Candidates must have a Ph.D. Interested applicants should submit a copy of their CV and contact information (email address and phone number) of three references to: Dr. Rolf Bodmer at rolf@sanfordburnham.org.
La Jolla, CA
Postdoctoral Training Opportunity
Development and Disease
Principal Investigator
Research Description
We seek individuals who are rigorous, productive, full of curiosity, have a persistent will to solve problems, always seeking new ideas and concepts, have effective communication skills, and who works well with others. The PI is devoted rigorous science and mentoring, emphasizing research philosophy and career advancement. Available projects range from basic developmental mechanisms and progenitor cell fate regulation, to modeling diseases, to genetic/chemical screens, and to in vivo genetic/chemical cell fate reprograming, and/or create your own projects. Please see our lab website.
Requirements
Postdoctoral candidates should have a Ph.D. or an M.D. with a solid background in molecular biology, development and genetics, or cell biology/biochemistry and at least one senior author publication. -omics experience is a plus.
La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Position
Principal Investigator
Alexey Terskikh, Ph.D.
Research Description
A post-doctoral fellow position is available in the laboratory of Alexey Terskikh, Development, Aging, and Regeneration Program, Sanford Burnham Medical Research Institute, La Jolla, California. The position focuses on understanding the role of SoxB1 factors in in self-renewal and differentiation of normal and neoplastic neural stem cell. A candidate will undertake a comprehensive analysis of SoxB1 interactome and function combining the expression analysis, proteome, and chromatin binding assays. The long-term goal of this project is to identify novel genes and pathways as well as develop small molecules either enhancing adult hippocampal neurogenesis or inducing differentiation of cancer “stem cells."
Requirements
The candidate must have a Ph.D. degree in any discipline of Biological Sciences. Skills in tissue culture, cell and molecular biology, fluorescent microscopy, computational biology and writing skills are required. Experience with transgenic mice model is highly desirable.

Interested candidates should contact the PI, Dr. Alexey Terskikh at Terskikh@sanfordburnham.org.

Please send a detailed resume, summary of previous work, electronic reprints of recent publications, and names and contact information for three references.

Bioinformatics and Structural Biology

La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Position
Principal Investigator
Niels Volkmann, Ph.D.
Research Description
A postdoctoral position is immediately available in the laboratory of Dr. Niels Volkmann, Sanford-Burnham Medical Research Institute (SBMRI), located on the Torrey Mesa in La Jolla, walking distance from Salk, Scripps, and UCSD (La Jolla, CA, USA).

Our research focuses on the development and application of approaches for structure determination of small and structurally heterogeneous macromolecules by cryo-EM (many of them helical) as well as for reconstruction and interpretation of cellular tomograms obtained by cryo-electron tomography. All work will be conducted in close collaboration with Dr. Dorit Hanein’s experimental cryo-EM group at SBMRI.
Requirements
The successful candidate should be highly motivated and have a PhD in structural biology, image processing or a related subject, good communication skills and a strong analytical mind. Preference will be given to experts in algorithm design and scientific computer programming with a proven interest in structural biology and to candidates who have excellent skills in experimental cryo-EM and application of structure determination approaches such as single-particle, helical, or tomographic reconstruction methods.

Candidates should send a CV, statement of research interest and focus, and provide the contact information for at least three professional references to Dr. Niels Volkmann, niels@sanfordburnham.org.

Cardiovascular Pathobiology

Lake Nona, FL
Postdoctoral Training Opportunity
Postdoctoral Associate
Principal Investigator
Layton Smith, Ph.D.
Research Description
A post-doctoral position is available to study mechanisms by which the peptide hormone apelin and its receptor influence cardiovascular and metabolic homeostasis. The laboratory currently has two extramurally funded projects in this area: 1) identification of signaling pathways underlying the pro-angiogenic effects of apelin and 2) development of apelin receptor antagonists for therapeutic applications. Post-doctoral research will include experimental design and execution, and interpretation of results obtained using various in vitro assays with the goal of defining the molecular pathways regulated by apelin, as well as characterizing the pharmacology and mechanism of action of novel small molecule antagonists of the apelin receptor.

These projects combine state-of-the-art approaches for determining receptor pharmacology, and mechanistic studies using molecular biology and cell-based assays. It is anticipated that the successful post-doctoral research associate will interface with the broader research group to advance related projects within the group.
Sanford-Burnham Medical Research Institute at Lake Nona (Orlando) is an independent, not-for-profit biomedical research institution dedicated to advancing the frontiers of scientific knowledge in life sciences and medicine with an emphasis on research on Diabetes and Obesity.

The Lake Nona/Orlando site has several outstanding technology cores for modern molecular and chemical biology research, with a strong interdisciplinary collaborative approach to scientific study.  There are also opportunities for clinical/translational studies via a strong collaborative interaction between the Sanford-Burnham Lake Nona site and the Translational Research Institute for Metabolism and Diabetes at the Florida Hospital.
Requirements
Candidates must have a Ph.D. and/or M.D. and a strong background in one of the following areas: vascular biology, cell/molecular biology, pharmacology.  Experience with transgenic mouse models, and/or in vitro and in vivo angiogenesis assays is a plus.  It is important that the candidate have excellent communication and interpersonal skills and the ability to work within an interdisciplinary team.

Interested applicants should submit a cover letter indicating research accomplishments and interests, CV, and contact information for at least 3 references as a single PDF or Word document to: sarah@sanfordburnham.org
Lake Nona, FL
Postdoctoral Training Opportunity
Postdoctoral Positions
Principal Investigators
Summary
A unique Postdoctoral Research Associate position that will provide intensive training and the opportunity to drive a molecular physiology project with translational links to human muscle disuse atrophy and de-training. The work will be performed in a multi-disciplinary team laboratory setting with world renowned expertise in myocyte energy metabolism, mitochondrial function and muscle physiology.
 
Research Focus
Exercise is known to protect against muscle atrophy in various types of muscle wasting, however, the underlying mechanisms remain unknown. It has been long known that muscle contraction improves mitochondrial content and function.  Recently the transcriptional regulators, including members of the PGC and ERR families that mediate this effect, have been discovered. Recent studies utilizing rodent models of muscle atrophy have demonstrated that transgenic overexpression of PGC-1α and PGC-1β in mice cannot only maintain mitochondrial content/function but also prevent activation of FOXO, subsequent activation of MurF1 and Atrogin-1, and proteasome/autophagy mediated muscle protein breakdown. These exciting studies provide the first evidence linking the molecular circuitry that controls mitochondrial function to atrophy signaling, and leads to the key question regarding how such programs are linked. It is thought that this co-regulation is evolutionarily conserved to tailor the energetic capacity with energetic demand of the cell and muscle mass. The goal is to further understand how transcriptional regulation of mitochondrial energetics relates to atrophy signaling.  The long-term goal of this work is to identify novel therapeutic targets for a myriad of muscle and metabolic diseases.
 
Job Duties
Some aspects of the project named above will be performed by the postdoctoral trainee. The work that the postdoctoral trainee will perform will provide him/her with an opportunity to learn all aspects of molecular biology research including DNA, RNA and protein techniques including western blotting.  He/she will also learn aspects of mouse physiology studies including, but not limited to, skeletal muscle physiology and phenotyping.  These techniques include hindlimb suspension, organ harvest, mitochondrial function studies, as well as general mouse husbandry. Findings will be validated in human myocytes and tissue.

The work they will perform will provide them an opportunity to learn, among other things, how to prepare a research plan; specific research methods; how to interpret data; how to prepare for and conduct presentations, both verbal and written; leadership skills, how to best interact with others in a research setting; and more. Trainees will be expected to attend and interact in laboratory meetings; as well as to attend and present at formal and informal seminars, both on and off site. 
Requirements
Candidates must have a Ph.D. and/or M.D. and a strong background in animal physiology and molecular biology is desired. Candidates must be highly self-motivated, independent and possess strong verbal and written communication skills. Interested applicants should submit a single PDF file containing CV, a brief description of research interests and accomplishments to Ms. Teresa Leone at tleone@sanfordburnham.org

Metabolic Disease

Lake Nona, FL
Postdoctoral Training Opportunity
Postdoctoral Associate
Principal Investigator
Timothy Osborne, Ph.D.
Program Name
Metabolic Disease
Research Description
A Postdoctoral Associate position is available to study immune system regulation of mammalian lipid metabolism through cellular, molecular and genetic mechanisms.

Sanford-Burnham Medical Research Institute at Lake Nona (Orlando) is an independent, not-for-profit biomedical research institution dedicated to advancing the frontiers of scientific knowledge in life sciences and medicine with an emphasis on research on Diabetes and Obesity. Sanford-Burnham has recently finished building 175,000 sq.ft. state-of-the-art laboratory facilities for over 300 faculty and staff. The Lake Nona/Orlando site has several outstanding technology cores for modern molecular and metabolic research, with a strong interdisciplinary collaborative approach to scientific study.
Requirements
Candidates must have a Ph.D. and or M.D. and must have a strong background in technical skills in the following areas: mouse metabolism and inflammation including immunological methods such as immune cell isolation, phagocytosis, apoptosis, cytokine analysis, flow cytometry and immunohistochemistry as well as strong molecular and cell biology skills. Interested applicants should submit a cover letter including research accomplishments and interests, CV and names of at least three (3) references to pphelan@sanfordburnahm.org

Genomic Control of Metabolism

There are no postdoctoral training opportunities in this program at this time.

Conrad Prebys Center for Chemical Genomics

There are no postdoctoral training opportunities in this center at this time.
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