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Drug discovery case study: invadopodia and cancer metastasis
To determine how cells control invadopodia formation, Dr. Sara Courtneidge and colleagues screened a collection of chemical compounds to identify those that either promote or inhibit the process.
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Making cancer drugs work better
Dr. Masanobu Komatsu's team discovered a molecule that controls tumor vessel maturation—a counterintuitive approach that could improve cancer drug delivery.
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Meet a cancer researcher
Meet Dr. Aman Mann, a postdoctoral researcher in Sanford-Burnham’s NCI-designated Cancer Center.
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Studying tumor microenvironment
Growth and spread of cancer involves not just the tumor cells themselves, but also other cells, tissues, and molecules in the environment surrounding the tumor. Research in this program aims to understand the molecular basis of cell-to-cell interaction, cell adhesion and cell migration, how these processes are controlled in normal physiology, how this control is subverted in disease, and how to restore normal control with chemical or biological inhibitors.
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Researchers in this program take advantage of the Institute’s high-throughput screening and analysis facility in the
Conrad Prebys Center for Chemical Genomics to identify chemical compounds that inhibit the cellular processes that allow cancer cells to proliferate. While much of our research is focused on cancer, these studies also have clear relevance to a number of other diseases, especially inflammatory and nervous system disorders.
The program is also home to Sanford-Burnham’s
Vascular Mapping Center—where phage display technology is used to identify peptides that home to individual tumors. An additional strength of the program is its strong expertise in glycosylation, a cellular process fundamental to many different diseases.
How our research helps improve health
Research in this program, combined with that of the other programs in the NCI-designated Cancer Center and the Conrad Prebys Center for Chemical Genomics, holds potential for the discovery of new cancer drugs and more safe and effective ways to deliver those drugs to the affected areas while minimizing side effects.
Research - Cancer - Tumor Microenvironment: How Our Research Helps |
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Notch increases the shedding of HB-EGF by ADAM12 to potentiate invadopodia formation in hypoxia.
Díaz B, Yuen A, Iizuka S, Higashiyama S, Courtneidge SA.
J Cell Biol. 2013 Apr 15;201(2):279-92. doi: 10.1083/jcb.201209151.
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c-Myc phosphorylation by PKCζ represses prostate tumorigenesis.
Kim JY, Valencia T, Abu-Baker S, Linares J, Lee SJ, Yajima T, Chen J, Eroshkin A, Castilla EA, Brill LM, Medvedovic M, Leitges M, Moscat J, Diaz-Meco MT.
Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6418-23. doi: 10.1073/pnas.1221799110. Epub 2013 Apr 2.
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Bidirectional myoblast-pericyte plasticity.
Stallcup WB.
Dev Cell. 2013 Mar 25;24(6):563-4. doi: 10.1016/j.devcel.2013.02.018.
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Bit1 in anoikis resistance and tumor metastasis.
Jenning S, Pham T, Ireland SK, Ruoslahti E, Biliran H.
Cancer Lett. 2013 Jun 10;333(2):147-51. doi: 10.1016/j.canlet.2013.01.043. Epub 2013 Jan 31.
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Control of nutrient stress-induced metabolic reprogramming by PKCζ in tumorigenesis.
Ma L, Tao Y, Duran A, Llado V, Galvez A, Barger JF, Castilla EA, Chen J, Yajima T, Porollo A, Medvedovic M, Brill LM, Plas DR, Riedl SJ, Leitges M, Diaz-Meco MT, Richardson AD, Moscat J.
Cell. 2013 Jan 31;152(3):599-611. doi: 10.1016/j.cell.2012.12.028.
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Liposomal fasudil, a rho-kinase inhibitor, for prolonged pulmonary preferential vasodilation in pulmonary arterial hypertension.
Gupta V, Gupta N, Shaik IH, Mehvar R, McMurtry IF, Oka M, Nozik-Grayck E, Komatsu M, Ahsan F.
J Control Release. 2013 Apr 28;167(2):189-99. doi: 10.1016/j.jconrel.2013.01.011. Epub 2013 Jan 23.
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View All Publications
Research - Cancer - Tumor Microenvironment: Recent Publications |
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c-Myc phosphorylation by PKCζ represses prostate tumorigenesis.
Kim JY, Valencia T, Abu-Baker S, Linares J, Lee SJ, Yajima T, Chen J, Eroshkin A, Castilla EA, Brill LM, Medvedovic M, Leitges M, Moscat J, Diaz-Meco MT
Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6418-23
Control of nutrient stress-induced metabolic reprogramming by PKCζ in tumorigenesis.
Ma L, Tao Y, Duran A, Llado V, Galvez A, Barger JF, Castilla EA, Chen J, Yajima T, Porollo A, Medvedovic M, Brill LM, Plas DR, Riedl SJ, Leitges M, Diaz-Meco MT, Richardson AD, Moscat J
Cell. 2013 Jan 31;152(3):599-611
Liposomal fasudil, a rho-kinase inhibitor, for prolonged pulmonary preferential vasodilation in pulmonary arterial hypertension.
Gupta V, Gupta N, Shaik IH, Mehvar R, McMurtry IF, Oka M, Nozik-Grayck E, Komatsu M, Ahsan F
J Control Release. 2013 Apr 28;167(2):189-99
Expedient synthesis of highly potent antagonists of inhibitor of apoptosis proteins (IAPs) with unique selectivity for ML-IAP.
Vamos M, Welsh K, Finlay D, Lee PS, Mace PD, Snipas SJ, Gonzalez ML, Ganji SR, Ardecky RJ, Riedl SJ, Salvesen GS, Vuori K, Reed JC, Cosford ND
ACS Chem Biol. 2013 Apr 19;8(4):725-32
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