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Muscle Development and Regeneration
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A few minutes with Dr. Mark Mercola
Dr. Mark Mercola directs Sanford-Burnham’s Muscle Development and Regeneration Program and is looking for ways to regenerate damaged heart tissue.
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Putting the muscle in muscle stem cells
Dr. Pier Lorenzo Puri and colleagues are figuring out ways to keep the muscle stem cell pool fresh and ready to regenerate injured or diseased muscle—a therapeutic approach that might one day benefit patients with muscular dystrophy.
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Studying muscle development and regeneration
The Muscle Development and Regeneration Program focuses on understanding the cause of and developing therapies for heart and skeletal muscle disorders with emphasis on three areas of research: 1) the molecular basis of congenital heart disease, 2) strategies for regeneration of heart and skeletal muscle cells for treatment of degenerative diseases, and 3) developmental basis and pathogenesis of myopathies, including muscle cell structural anomalies and pathological myocardial hypertrophy.
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This program builds on current strengths in mouse transgenic and surgical models of heart disease, including congenital heart disease, research on muscle stem and progenitor cells, and discovery of small molecule and microRNA regulators of muscle development that will be used to develop probes of muscle disease and drugs for therapy. The program’s focus complements the interests of the Cardiovascular Pathobiology Program, which emphasizes adult heart disease, the Development and Aging Program, which focuses on basic developmental biology and aging mechanisms, the Stem Cell and Regeneration Program, which focuses on broad issues of stem cell potency, differentiation and applications in regenerative medicine, and the RNA Biology Program, which is working to understand how the world of non-coding RNAs guides cellular processes in health and disease.
How our research helps improve health
Heart and skeletal muscle disorders contribute to substantial mortality and morbidity not only for adults but also for children and young adults. Researchers in the Muscle Development and Regeneration Program are developing therapies for these diseases.
Research - Children's Health - Muscle Development and Regeneration:
How Our Research Helps |
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Quantitative Transcriptomics using Designed Primer-based Amplification.
Bhargava V, Ko P, Willems E, Mercola M, Subramaniam S.
Sci Rep. 2013 Apr 29;3:1740. doi: 10.1038/srep01740.
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Fibroadipogenic progenitors mediate the ability of HDAC inhibitors to promote regeneration in dystrophic muscles of young, but not old Mdx mice.
Mozzetta C, Consalvi S, Saccone V, Tierney M, Diamantini A, Mitchell KJ, Marazzi G, Borsellino G, Battistini L, Sassoon D, Sacco A, Puri PL.
EMBO Mol Med. 2013 Apr;5(4):626-39. doi: 10.1002/emmm.201202096. Epub 2013 Mar 18.
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Epigenetic reprogramming of human embryonic stem cells into skeletal muscle cells and generation of contractile myospheres.
Albini S, Coutinho P, Malecova B, Giordani L, Savchenko A, Forcales SV, Puri PL.
Cell Rep. 2013 Mar 28;3(3):661-70. doi: 10.1016/j.celrep.2013.02.012. Epub 2013 Mar 7.
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Induced pluripotent stem cells in cardiovascular drug discovery.
Mercola M, Colas A, Willems E.
Circ Res. 2013 Feb 1;112(3):534-48. doi: 10.1161/CIRCRESAHA.111.250266. Review.
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Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs.
Kim C, Wong J, Wen J, Wang S, Wang C, Spiering S, Kan NG, Forcales S, Puri PL, Leone TC, Marine JE, Calkins H, Kelly DP, Judge DP, Chen HS.
Nature. 2013 Feb 7;494(7435):105-10. doi: 10.1038/nature11799. Epub 2013 Jan 27.
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Cardiovascular biology: A boost for heart regeneration.
Mercola M.
Nature. 2012 Dec 20;492(7429):360-2. doi: 10.1038/nature11763. Epub 2012 Dec 5.
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View All Publications
Research - Children's Health - Muscle Development and Regeneration:
Recent Publications |
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Fibroadipogenic progenitors mediate the ability of HDAC inhibitors to promote regeneration in dystrophic muscles of young, but not old Mdx mice.
Mozzetta C, Consalvi S, Saccone V, Tierney M, Diamantini A, Mitchell KJ, Marazzi G, Borsellino G, Battistini L, Sassoon D, Sacco A, Puri PL
EMBO Mol Med. 2013 Apr;5(4):626-39
Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs.
Kim C, Wong J, Wen J, Wang S, Wang C, Spiering S, Kan NG, Forcales S, Puri PL, Leone TC, Marine JE, Calkins H, Kelly DP, Judge DP, Chen HS
Nature. 2013 Feb 7;494(7435):105-10
View All Publications
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