This program builds on current strengths in mouse transgenic and surgical models of heart disease, including congenital heart disease, research on muscle stem and progenitor cells, and discovery of small molecule and microRNA regulators of muscle development that will be used to develop probes of muscle disease and drugs for therapy. The program’s focus complements the interests of the Cardiovascular Pathobiology Program, which emphasizes adult heart disease, the Development and Aging Program, which focuses on basic developmental biology and aging mechanisms, the Stem Cell and Regeneration Program, which focuses on broad issues of stem cell potency, differentiation and applications in regenerative medicine, and the RNA Biology Program, which is working to understand how the world of non-coding RNAs guides cellular processes in health and disease.
How our research helps improve health
Heart and skeletal muscle disorders contribute to substantial mortality and morbidity not only for adults but also for children and young adults. Researchers in the Muscle Development and Regeneration Program are developing therapies for these diseases.