Mutidisciplinary teams within the program study how extrinsic and intrinsic cell signaling networks integrate with gene-regulatory mechanisms involved in energy generation and storage pathways to influence the biologic and physiologic mechanisms of metabolic disease. This holistic approach is essential to understanding how different organ systems communicate together to provide metabolic balance for the entire body.
How our research helps improve health
When the metabolic system is out of balance due to genetic, environmental, or dietary factors, diseases such as obesity and diabetes develop. An estimated 60 percent of the U.S. adult population is overweight or obese. By understanding the molecular regulatory mechanisms that maintain metabolic homeostasis, our scientists can identify new drug targets that will be exploited for novel therapies to reverse the extreme rise in the incidence of type 2 diabetes that has occurred over the past several decades.