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Carl Ware & secrets of the immune system
Dr. Ware’s research focuses on the fundamental pathways that control cytokines, a family of proteins involved in immune signaling.
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New insight into mechanisms behind autoimmune diseases suggests a potential therapy
Sanford-Burnham researchers have found a potential new therapy for autoimmune diseases—a chemical compound that appears to inhibit a mutant form of the protein LYP.
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Study raises questions about lymphoma drugs
A study led by Robert Rickert, Ph.D. explored the roles of two enzymes, SHIP and PTEN, in B cell growth and proliferation. The results could impact several anti-lymphoma therapies currently in development.
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Studying inflammatory diseases
Researchers in the Inflammatory Disease Research Program are studying the central players in human inflammatory disease processes, the innate and adaptive immune systems, and the molecular mechanisms of diseases such as rheumatoid arthritis. Insights from these studies are used for the rational, structure-based design of new therapeutics. In addition to traditional cellular biochemistry and molecular biology, the program emphasizes study of human tissue samples and DNA, genetics, proteomics, bioinformatics, new imaging techniques, electron microscopy, structural biology, rational drug design, chemistry, protein engineering, and nanotechnology.
Research - Infectious and Inflammatory Disease - Inflammatory
Disease: About |
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Inflammation is the body’s basic response to a variety of external or internal insults, such as infectious agents, physical injury, hypoxia, or disease processes in nearly any organ or tissue in the body. Inflammation entails the four well-known symptoms—redness, heat, tenderness/pain and swelling—that characterize so many common diseases and conditions.
How our research helps improve health
Chronic inflammatory diseases, such as rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus, multiple sclerosis, and type 1 diabetes, affect more than 50 million Americans. Many of these diseases are debilitating and are becoming increasingly common in our aging society.
In Sanford-Burnham’s Inflammatory Disease Research Program, researchers have had significant success in identifying a gene variant associated with type 1 diabetes. This finding has now been expanded into rheumatoid arthritis and systemic lupus erythematosus. Other contributions include discoveries about specific genes and enzymes related to human disease, including infectious with the bacterium that causes anthrax.
Research - Infectious and Inflammatory Disease - Inflammatory
Disease: How Our Research Helps |
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Protein therapeutics targeted at the TNF superfamily.
Ware CF.
Adv Pharmacol. 2013;66:51-80. doi: 10.1016/B978-0-12-404717-4.00002-0.
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Lymphotoxin network pathways shape the tumor microenvironment.
Bjordahl RL, Steidl C, Gascoyne RD, Ware CF.
Curr Opin Immunol. 2013 Apr;25(2):222-9. doi: 10.1016/j.coi.2013.01.001. Epub 2013 Jan 20.
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Clinical targeting of the TNF and TNFR superfamilies.
Croft M, Benedict CA, Ware CF.
Nat Rev Drug Discov. 2013 Feb;12(2):147-68. doi: 10.1038/nrd3930. Epub 2013 Jan 21. Review.
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The autoimmune-predisposing variant of lymphoid tyrosine phosphatase favors T helper 1 responses.
Vang T, Landskron J, Viken MK, Oberprieler N, Torgersen KM, Mustelin T, Tasken K, Tautz L, Rickert RC, Lie BA.
Hum Immunol. 2013 May;74(5):574-85. doi: 10.1016/j.humimm.2012.12.017. Epub 2013 Jan 17.
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Identification of small molecules that interfere with H1N1 influenza A viral replication.
Bottini A, De SK, Baaten BJ, Wu B, Barile E, Soonthornvacharin S, Stebbins JL, Bradley LM, Chanda SK, Pellecchia M.
ChemMedChem. 2012 Dec;7(12):2227-35. doi: 10.1002/cmdc.201200453. Epub 2012 Nov 8.
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Subnuclear cyclin D3 compartments and the coordinated regulation of proliferation and immunoglobulin variable gene repression.
Powers SE, Mandal M, Matsuda S, Miletic AV, Cato MH, Tanaka A, Rickert RC, Koyasu S, Clark MR.
J Exp Med. 2012 Nov 19;209(12):2199-213. doi: 10.1084/jem.20120800. Epub 2012 Oct 29.
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Research - Infectious and Inflammatory Disease - Inflammatory
Disease: Recent Publications |
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