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Brain enzyme is double whammy for Alzheimer’s disease
Dr. Huaxi Xu's research discovered that BACE1, an enzyme that produces b-amyloid also regulates another cellular process that contributes to memory loss.
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Searching for causes of neuron death in Alzheimer’s and TBI
Sanford-Burnham researchers discovered that the protein appoptosin prompts neurons to commit suicide in several neurological conditions.
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Using stem cells to treat Parkinson’s disease
Dr. Stuart Lipton has discovered a possible method to use MEF2C-programmed human stem cells for treatment of Parkinson's disease.
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Studying degenerative disease
The Degenerative Disease Research Program seeks to understand the fundamental molecular changes responsible for cell and tissue degeneration in the nervous system and other organs. Researchers in this program study degenerative diseases such as stroke, Alzheimer's disease, Parkinson's disease, Lou Gehrig's disease, Huntington's disease, HIV-associated dementia, diabetes, and glaucoma.
Research - Neuroscience, Aging and Stem Cell - Degenerative
Disease: About |
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Our degenerative disease researchers are a highly collaborative, multidisciplinary group with combined expertise in neurotransmitter receptor/ion-channel electrophysiology, mouse models of stroke and neurodegeneration, nitrosyl-free radical chemistry, and signal transduction research.
How our research helps improve health
Discoveries made by scientists in this program have paved the way for development of a drug for Alzheimer's disease that, for the first time, gets to the root of the problem, possibly preventing brain cell death rather than merely masking symptoms caused by loss of these cells. A number of other strategies are now being developed for either protecting cells or replacing cells lost due to degenerative diseases of the brain and other organs.
Research - Neuroscience, Aging and Stem Cell - Degenerative
Disease: How Our Research Helps |
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Research - Neuroscience, Aging and Stem Cell - Degenerative Disease:
Recent Developments
Recent Developments
Your support is crucial in turning hope into healing. Learn More
Using stem cells to treat Parkinson’s disease
A team led by Dr. Stuart Lipton discovers how stem cells can be used to generate dopamine-producing neurons and how these cells show therapeutic benefit in a rodent model of Parkinson’s disease.
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ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death.
Han J, Back SH, Hur J, Lin YH, Gildersleeve R, Shan J, Yuan CL, Krokowski D, Wang S, Hatzoglou M, Kilberg MS, Sartor MA, Kaufman RJ.
Nat Cell Biol. 2013 May;15(5):481-90. doi: 10.1038/ncb2738. Epub 2013 Apr 28.
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S-nitrosylated SHP-2 contributes to NMDA receptor-mediated excitotoxicity in acute ischemic stroke.
Shi ZQ, Sunico CR, McKercher SR, Cui J, Feng GS, Nakamura T, Lipton SA.
Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3137-42. doi: 10.1073/pnas.1215501110. Epub 2013 Feb 4.
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The unfolded protein response and chemical chaperones reduce protein misfolding and colitis in mice.
Cao SS, Zimmermann EM, Chuang BM, Song B, Nwokoye A, Wilkinson JE, Eaton KA, Kaufman RJ.
Gastroenterology. 2013 May;144(5):989-1000.e6. doi: 10.1053/j.gastro.2013.01.023. Epub 2013 Jan 18.
Read More
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Targeting endoplasmic reticulum stress in metabolic disease.
Cao SS, Kaufman RJ.
Expert Opin Ther Targets. 2013 Apr;17(4):437-48. doi: 10.1517/14728222.2013.756471. Epub 2013 Jan 17.
Read More
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ER stress signalling through eIF2α and CHOP, but not IRE1α, attenuates adipogenesis in mice.
Han J, Murthy R, Wood B, Song B, Wang S, Sun B, Malhi H, Kaufman RJ.
Diabetologia. 2013 Apr;56(4):911-24. doi: 10.1007/s00125-012-2809-5. Epub 2013 Jan 12.
Read More
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IRE1, a double-edged sword in pre-miRNA slicing and cell death.
Hassler J, Cao SS, Kaufman RJ.
Dev Cell. 2012 Nov 13;23(5):921-3. doi: 10.1016/j.devcel.2012.10.025.
Read More
View All Publications
Research - Neuroscience, Aging and Stem Cell - Degenerative
Disease: Recent Publications
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S-nitrosylated SHP-2 contributes to NMDA receptor-mediated excitotoxicity in acute ischemic stroke.
Shi ZQ, Sunico CR, McKercher SR, Cui J, Feng GS, Nakamura T, Lipton SA.
Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3137-42. doi: 10.1073/pnas.1215501110. Epub 2013 Feb 4.
Read More
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The unfolded protein response and chemical chaperones reduce protein misfolding and colitis in mice.
Cao SS, Zimmermann EM, Chuang BM, Song B, Nwokoye A, Wilkinson JE, Eaton KA, Kaufman RJ.
Gastroenterology. 2013 May;144(5):989-1000.e6. doi: 10.1053/j.gastro.2013.01.023. Epub 2013 Jan 18.
Read More
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Targeting endoplasmic reticulum stress in metabolic disease.
Cao SS, Kaufman RJ.
Expert Opin Ther Targets. 2013 Apr;17(4):437-48. doi: 10.1517/14728222.2013.756471. Epub 2013 Jan 17.
Read More
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ER stress signalling through eIF2α and CHOP, but not IRE1α, attenuates adipogenesis in mice.
Han J, Murthy R, Wood B, Song B, Wang S, Sun B, Malhi H, Kaufman RJ.
Diabetologia. 2013 Apr;56(4):911-24. doi: 10.1007/s00125-012-2809-5. Epub 2013 Jan 12.
Read More
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IRE1, a double-edged sword in pre-miRNA slicing and cell death.
Hassler J, Cao SS, Kaufman RJ.
Dev Cell. 2012 Nov 13;23(5):921-3. doi: 10.1016/j.devcel.2012.10.025.
Read More
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High-frequency hippocampal oscillations activated by optogenetic stimulation of transplanted human ESC-derived neurons.
Piña-Crespo JC, Talantova M, Cho EG, Soussou W, Dolatabadi N, Ryan SD, Ambasudhan R, McKercher S, Deisseroth K, Lipton SA.
J Neurosci. 2012 Nov 7;32(45):15837-42. doi: 10.1523/JNEUROSCI.3735-12.2012.
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View All Publications
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