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 Overview
The Assay Development Facility provides support in design and development of new and optimization of existing HTS assays. Our dedicated staff is skilled in various screening modalities to help with selection and development of assays most suitable to each particular project. The facility also provides support for Structure-Activity Relationship (SAR) studies aimed at characterization and optimization of hits obtained in primary screening. You can access assay development resources through our La Jolla or Lake Nona facility.
The facility is a part of Conrad Prebys Center for Chemical Genomics and can advise and help in preparation of data packages for screening-related grants. |
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Basics of HTS Assay Design and Optimization in Chemical Genomics. 2012.
Sergienko EA.
Chapter 12. pp.159-172. Cambridge University Press, New York. ISBN:9780521889483
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A high-throughput screen for inhibitors of xenobiotic detoxification in nematodes.
Chi K Leung, Siobhan Malany, Andrew S. Deonarine, Ying Wang, and Keith P. Choe.
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Inhibition of hematopoietic protein tyrosine phosphatase augments and prolongs ERK1/2 and p38 activation.
Sergienko E, Xu J, Liu WH, Dahl R, Critton DA, Su Y, Brown BT, Chan X, Yang L, Bobkova EV, Vasile S, Yuan H, Rascon J, Colayco S, Sidique S, Cosford ND, Chung TD, Mustelin T, Page R, Lombroso PJ, Tautz L.
ACS Chem Biol. 2012 Feb 17;7(2):367-77. doi: 10.1021/cb2004274. Epub 2011 Nov 17.
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High-throughput screening of tissue-nonspecific alkaline phosphatase for identification of effectors with diverse modes of action.
Sergienko EA, Millán JL.
Nat Protoc. 2010 Aug;5(8):1431-9. Epub 2010 Jul 15.
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Assay format as a critical success factor for identification of novel inhibitor chemotypes of tissue-nonspecific alkaline phosphatase from high-throughput screening.
Chung TD, Sergienko E, Millán JL.
Molecules. 2010 Apr 27;15(5):3010-37.
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Identification and characterization of novel tissue-nonspecific alkaline phosphatase inhibitors with diverse modes of action.
Sergienko E, Su Y, Chan X, Brown B, Hurder A, Narisawa S, Millán JL.
J Biomol Screen. 2009 Aug;14(7):824-37. Epub 2009 Jun 25.
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Tech - Shared Resources: Prebys Center Links Related
Links to Related Sanford-Burnham Core Services
The Conrad Prebys Center of Chemical Genomics provides a comprehensive suite of capabilities
for preclinical small molecule drug discovery by providing specialized expertise within our eight core facilities:
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