The Stem Cell Core (SCC) at Sanford-Burnham provides scientists within the community the opportunity to conduct their research devoted to human stem cells and that is conducive to collaborative partnerships. The SCC staff has extensive experience in maintenance, characterization, and differentiation of human embryonic stem cells (hESC) and the generation of non-integrated hiPSC from skin fibroblasts and lymphocytes using episomal, modified mRNA, or Sendai viral method. The SCC provides researchers with a source of various embryonic stem cell lines and carries a wide variety of validated stem cell reagents for hESC/hiPSC culture that are available for purchase. Hands-on and individual ad hoc training courses on hESC maintenance, characterization, and hiPSC generation are available for investigators and scientists. Extensive equipment for growth and characterization of stem cells is available for use in the core.